Brooke Greenberg may look like an infant, but she is actually 20
years old. Despite her increasing age, Brooke has remained physically and
cognitively similar to a toddler, with an estimated mental age of nine months
to one year. Brooke, who is from Maryland, is unable to talk, still has her
baby teeth and like any infant, travels in a push chair - but doctors have
never been able to explain why. Her father, Howard Greenberg, explained: 'From
age one to four, Brooke changed. She got a little bit bigger. But age four,
four to five, she stopped. 'She has been examined by some of the most
prestigious medical institutions in the U.S., however no formal diagnosis for
Brooke’s condition has been given, leading doctors to term her condition
Syndrome X. Dr Eric Schadt, director of the Icahn Institute for Genomics and
Multiscale Biology at The Mount Sinai Medical Center in New York, explained
that she has 'no apparent abnormalities in her endocrine system, no gross
chromosomal abnormalities, or any of the other disruptions known to occur in
humans that can cause developmental issues.'
Brooke, who has stayed the same size for 15 years, requires
24-hour care from her parents. She is fed through a tube inserted into her
stomach, because her oesophagus is so small that swallowed food could back up
into her lungs and cause pneumonia. Her mother, Melanie Greenberg, said: 'It's
been 16 years of on the job training, giving her medicine, knowing when she's
sick, knowing the right amount. 'Mr Greenberg added: 'The key with Brooke is we
don't know what tomorrow brings.'
Scientists believe her unique genetic code could provide a fresh
insight into the process of aging, leading to the development of new treatments
for diseases related to old age, such as Parkinson's. Tests have shown that
Brooke, who was born in 1993, may suffer from a gene mutation that switches off
her ability to mature. Dr Schadt is in the process of sequencing Brooke’s
genome, which is comprised of two long strings of letters, one from the mother
and one from the father. Each string is three billion letters long, and changes
in just one of these letters can lead to profound effects on development,
physical appearance, and risk of disease. In the first six years of her life,
Brooke suffered series of medical emergencies from which she recovered, often
without explanation. She survived surgery for seven perforated stomach ulcers,
and suffered a brain seizure followed by a stroke that weeks later left no
apparent damage. Then at age four, she fell into a coma that caused her to
sleep for 14 days. Doctors diagnosed a brain tumor, which disappeared by the
time she awoke.
Key to aging: Scientists believe Brooke's unique genetic code
could provide a fresh insight into the process of ageing, leading to the
development of new treatments for diseases related to old age, such as
Parkinson's Dr Schadt hopes to find out whether any abnormal genes
identified in Brooke 'are involved in aging related processes, whether
manipulating these genes could increase longevity and/or reduce aging related
disorders such as Alzheimer’s, heart disease and many forms of cancer,' he
said. Mrs Greenberg, who said she loves Brooke the way she is, explained that
if another mother with a toddler asks her how old Brooke is, she usually
doesn't answer truthfully. 'My system always has been to turn years into
months. So, if someone asked today, I might say, she's [20] months old,' she
said.